The normal alveolar-arterial oxygen-tension gradient in man.

Blood oxygenation during hyperpressure intraperitoneal fluid administration in a rabbit model of severe liver injury: Evaluation of a novel concept for control of pre-hospital liver bleeding

Oxygen is an essential part of the most important metabolic pathways in aerobic organisms. Oxygen delivery is merely dependent on blood, rendering blood loss a devastating event. Traumatic pre-hospital liver bleeding is a major cause of early trauma deaths in human and animals, with no established therapeutic method yet. Increasing intra-abdominal pressure (IAP) has been shown to reduce liver b...

Hypoxic ventilatory drive in normal man.

A technique is described which permits the inscription of the ventilatory response to isocapnic hypoxia in man as a continuous curve relating alveolar oxygen tension and minute ventilation. The adjustment of ventilation to changes in alveolar oxygen tension is complete in 18-23 sec and this is sufficiently rapid to justify the use of a non-steady-state method. Changes in alveolar carbon dioxide...

Alveolar and arterial oxygen tensions and the significance of the alveolar-arterial oxygen tension difference in normal men.

Studies of peripheral circulation during sickle-cell crisis.

IT IS WELL recognized that patients with sickle-cell disease may have a low saturation and tension of arterial blood oxygen. Although arterial anioxemia was first observed in 1942, its exact mechanism is still unknown.1 It has been shown that the hemoglobin dissociation curve of these patients is shifted to the right, probably because of a decrease in erythrocyte pH.2, 3 Therefore, a norimal le...

Blood-gas changes and pulmonary hemodynamics following acute myocardial infarction.

SUMMARY Arterial and mixed venous oxygen tensions were measured in 24 patients following acute myocardial infarction while they were breathing air and 100% oxygen. Total venous admixture and the right-to-left shunt during 100% oxygen breathing were calculated. These data were related to the pulmonary arterial diastolic pressure, the cardiac index, and the central blood volume. Patients with myo...